• The University of Texas at Austin (Austin, TX, Aug. 2004 – Aug. 2009)

     Ph.D. Chemical Engineering

     Thesis: Engineering of Aglycosylated Antibody Fc for Effector Functions

• Seoul National University (Seoul, Korea, Mar. 1997 – Feb. 1999)

     M.S. Chemical Technology (now Chemical and Biological Engineering)

     Thesis: Production and Purification of Recombinant Human Erythropoietin in Escherichia coli and Chemical Modification with Monomethoxy Polyethylene Glycol

• Associate Professor (Seoul, Korea, Sep. 2024 – Present)

     Department of Chemical and Biological Engineering, Seoul National University

     Antibody Engineering, Protein Engineering, and Applied Immunology

• Associate Professor / Professor(Seoul, Korea, Mar. 2019 – Aug. 2024)

     Department of Biomedical Sciences, Graduate School of Medicine, Korea University

     Antibody Engineering, Protein Engineering, and Applied Immunology

• Visiting Professor (Austin, TX, Jul. 2023 – Feb. 2024)

     Department of Chemical Engineering, The University of Texas at Austin

     Antibody and Protein Engineering

• Assistant Professor / Associate Professor (Seoul, Korea, Sep. 2012 – Feb. 2019)

     Department of Applied Chemistry, Kookmin University

     Antibody Engineering, Protein Engineering, and Applied Immunology

• Research Associate, Staff Scientist (Austin, TX, May. 2011 – Aug. 2012)

     Department of Chemical Engineering, The University of Texas at Austin 

     Advisor: Prof. George Georgiou

     Applied Immunology:

     - Antibody discovery via proteomic tools and bioinformatic analysis

     - Recruitment of endogenous antibodies for cancer immunotherapy

     - Engineering antibody for enhanced potency and stability

• Post-Doctoral Fellow (Pasadena, CA, Jun. 2010 – May. 2011)

     Division of Chemistry and Chemical Engineering, California Institute of Technology

     Advisor: Prof. Frances H. Arnold, Nobel Prize Laureate in Chemistry (2018)

     Evolutionary Design of Biological Systems:

     - Directed evolution of cytochrome P450 heme domain for ligand specific functional MRI contrast agents

     - Enzyme evolution for non-natural heme-incorporated proteins

     - Directed evolution of cytochrome P450 BM3 for chemicals and biofuels

• Post-Doctoral Fellow (Austin, TX, Aug. 2009 – May. 2010)

     Department of Chemical Engineering, The University of Texas at Austin

     Advisor: Prof. George Georgiou

     Antibody Engineering:

    - Engineering antibodies for selective binding to activating low affinity Fc receptors and enhanced therapeutic effector functions

       functions.

    - Designing and screening of antibodies for improved HIV neutralization.

• Graduate Research Fellow (Research Assistant and Teaching Assistant) (Austin, TX, Aug. 2004 – Aug. 2009)

     Department of Chemical Engineering, The University of Texas at Austin

     Advisor: Prof. George Georgiou

     Antibody Engineering, High Throughput Screening, and Bacteria Physiology:

     - Engineering of aglycosylated antibody Fc for unique effector functions

     - Development of a high throughput antibody screening system for insoluble antigens

     - Development of covalently anchored full-length IgG display system

     - Bacterial production and characterization of human Fc receptors

• Research Scientist (Daejeon, Korea, May. 2001 – Mar. 2004)

     Samyang Genex Biotech Research Institute

     Development of Protein Therapeutics:

     - Development of fermentation and purification process for human G-CSF from E. coli

     - Genetic optimization for high-level expression of G-CSF in E. coli

     - Cloning, production, and characterization of lysyl oxidase family proteins for anticancer drugs

• Researcher (Yongin, Korea, Dec. 1998 – Apr. 2001)

     Green Cross Corporation

     Development of Vaccines and Diagnostics:

Researcher in Rotavirus Vaccine Research Team

     - Scale-up to 75L scale and optimization of baculovirus-infected insect cell (Sf9) culture for the production of rotavirus-like particle (VLP) vaccine

     - Development of purification process for rotavirus-like particle vaccine

     - Development of rotavirus detection kit (Rotatek™)

• Graduate Research Fellow (Research and Teaching Assistant) (Seoul, Korea, Mar. 1997 – Feb. 1999)

     Seoul National University

     Advisor: Prof. Cha Yong Choi

     Protein Engineering:

     - Production and purification of human erythropoietin in E. coli

     - Chemical modification of human erythropoietin using polyethylene glycol for the enhancement of half-life and serum stability